Vitamin D3 Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts
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چکیده
منابع مشابه
Expression of translationally controlled tumour protein is regulated by calcium at both the transcriptional and post-transcriptional level.
We have investigated how the programme of protein synthesis is altered in response to a loss of calcium homoeostasis in Cos-7 cells using a differential proteome mapping approach. Exposure of the cells to the calcium ionophore A23187 or thapsigargin, or alternatively, expression of a viral glycoprotein reported to deplete intracellular calcium stores, resulted in the up-regulated expression of ...
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Thank you again for submitting your manuscript to The EMBO Journal. I need to apologize for the undue delay in getting back to you with a decision, which was owed to one of the referees unfortunately being very late in sending their report. We have now finally received all three sets of comments, copied below for your information. As you will see, the referees express (to varying degrees) inter...
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Although ERs (oestrogen receptors) mediate breast tumour behaviour, the precise role of ERbeta remains unclear. This is mainly because analyses have been complicated by the presence in breast tissue of three ERbeta protein variants (ERbeta1, ERbeta2 and ERbeta5) that derive from differential 3' splicing. We have recently identified the first known mechanisms responsible for the differential con...
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FBXO31, a subunit of the SCF ubiquitin ligase, played a crucial role in neuronal development, DNA damage response and tumorigenesis. Here, we investigated the expression and prognosis value of FBXO31 in human primary gastric cancer (GC) samples. Meanwhile, the biological role and the regulation mechanism of FBXO31 were evaluated. We found that FBXO31 mRNA and protein was decreased dramatically ...
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STUDY QUESTION Can plasma microRNAs be used as a non-invasive diagnostic test for the detection of endometriosis? SUMMARY ANSWER Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis compared with those without endometriosis in mainland China. WHAT IS KNOWN ALREADY There is currently a pressing need to develop a non-invasive diagnostic test for endometriosis. A...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.068387